Wacker: Analysis of Formulations of Curcumin for Relative Oral Bioavailability in Human Subjects
The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption.
Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility and absorption.
This double-blinded, cross-over study investigated twelve healthy human volunteers. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-hour period.
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